Journal: PLoS ONE
Article Title: Community development, implementation, and assessment of a NIBLSE bioinformatics sequence similarity learning resource
doi: 10.1371/journal.pone.0257404
Figure Lengend Snippet: Sequence similarity learning resource module descriptions.
Article Snippet: Module 3: Phylogenetic Analysis of Homologous Sequences , Students practice accessing text-based FASTA-formatted sequence information via the National Center for Biotechnology Information (NCBI) databases as they collect protein sequence data for a multiple sequence alignment for the generation of a phylogenetic tree. Students construct a small tree manually using the Neighbor Joining algorithm. This core concept and competency has utility for biologists seeking to identify conserved protein domains and key conserved amino acid residues associated with structure and function within a domain in addition to allowing for visual depiction of evolutionary relationships between three or more sequences..
Techniques: Sequencing, Functional Assay, Construct